求助药物化学专业英语翻译?

大家可以翻译一下这个文章不啊?
 Text Two
Glossary of Terms Used in Medicinal Chemistry(2)
(IUPAC Recommendations 1998)
1,IND: Abbreviation for Investigational New Drug.
2,Intrinsic activity: Intrinsic activity is the maximal stimulatory response induced by a compound in relation to that of a given reference compound.
3,This term has evolved with common usage. It was introduced by Ariëns as a proportionality factor between tissue response and receptor occupancy. The numerical value of intrinsic activity (alpha) could range from unity (for full agonists, i.e., agonist inducing the tissue maximal response) to zero (for antagonists), the fractional values within this range denoting partial agonists. Ariëns' original definition equates the molecular nature of alpha to maximal response only when response is a linear function of receptor occupancy. This function has been verified. Thus, intrinsic activity, which is a drug and tissue parameter, cannot be used as a characteristic drug parameter for classification of drugs or drug receptors. For this purpose, a proportionality factor derived by null methods, namely, relative efficacy, should be used. Finally, "intrinsic activity" should not be used instead of "intrinsic efficacy". A "partial agonist" should be termed "agonist with intermediate intrinsic efficacy" in a given tissue.
4,Inverse agonist: An inverse agonist is a drug which acts at the same receptor as that of an agonist, yet produces an opposite effect. Also called negative antagonists.
5,Lead discovery: Lead discovery is the process of identifying active new chemical entities, which by subsequent modification may be transformed into a clinically useful drug.
6,Lead optimization: Lead optimization is the synthetic modification of a biologically active compound, to fulfill all stereoelectronic, physicochemical, pharmacokinetic and toxicologic required for clinical usefulness.
7,Lipophilicity: Lipophilicity represents the affinity of a molecule or a moiety for a lipophilic environment. It is commonly measured by its distribution behaviour in a biphasic system, either liquid-liquid (e.g., partition coefficient in octan-1-ol/water) or solid/liquid (retention on reversed-phase high performance liquid chromatography (RP-HPLC) or thin-layer chromatography (TLC) system).
8,Medicinal chemistry: Medicinal chemistry is a chemistry-based discipline, also involving aspects of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships.
专业的英语,不是直接英语过来,不然不通顺的.

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2008-05-28 回答
文本二用于医药Chemistry(2)的用语Glossary 
(IUPAC推荐1998)
1,IND : 对调查新的药物的简称。
2,Intrinsic活动: 内在活动是化合物导致的最大的激动反应关于那一种特定参考化合物。
3,This期限演变了与共同的用法。 arienss介绍它作为在组织反应和感受器官居住之间的一个比例因子。 内在活动(阿尔法)的数值可能从团结范围(即,为充分的收缩筋导致组织最大的反应)的收缩筋到零(为反对者),在表示部份收缩筋的这个范围之内的分数价值。 只有当反应是感受器官居住时的一个线性函数Ariëns的原始的定义视同阿尔法的分子本质对最大的反应。 这个作用被核实了。 因此,内在活动,是药物和组织参量,不可能使用作为一个典型药物参量为药物或药物感受器官的分类。 为此,应该使用衡消法获得的比例因子,即,相对效力。 终于, “不应该使用内在活动”而不是“内在效力”。 应该命名“部份收缩筋” “与中间内在效力的收缩筋”在一个特定组织。
4,Inverse收缩筋: 一个相反收缩筋是作为在同一种感受器官那收缩筋的药物,导致一个相反作用。 并且告诉的消极反对者。
5,Lead发现: 主角发现是辨认活跃新的化学个体的过程,由随后修改也许被变换成一种临床有用的药物。
6,Lead优化: 主角优化是一种生物活跃化合物的综合性修改,履行所有stereoelectronic,物理化学,约物动力学和毒理学必需临床有用性的。
7,Lipophilicity : Lipophilicity代表分子的亲合力或一个亲油性环境的份额。 它由它的在一个双相的系统的发行行为共同地测量, liquid-liquid (即,在octan-1-ol/water的分开系数)或坚实或者液体(在反回阶段高性能液相色谱(RP-HPLC)或薄层色谱法(TLC)系统的)保留。
8,Medicinal化学: 医药化学是一个基于化学的学科,也介入生物,医疗和配药科学的方面。 它与发明、发现、设计、生物激活化合物的证明和准备有关,他们的新陈代谢的研究,行动他们的方式的解释在分子水平的和结构活动关系的建筑。